Universitätsklinikum der Heinrich-Heine Universität Düsseldorf

Hier entsteht eine alphabetisch sortierte Auswahl von herausragenden Publikationen der Medizinischen Fakultät.

• Albers P, Siener R, Krege S, Schmelz HU, Dieckmann KP, Heidenreich A, Kwasny P, Pechoel M, Lehmann J, Kliesch S, Köhrmann KU, Fimmers R, Weissbach L, Loy V, Wittekind C, Hartmann M; German Testicular Cancer Study Group. Randomized phase III trial comparing retroperitoneal lymph node dissection with one course of bleomycin and etoposide plus cisplatin chemotherapy in the adjuvant treatment of clinical stage I Nonseminomatous testicular germ cell tumors: AUO trial AH 01/94 by the German Testicular Cancer Study Group. J Clin Oncol. 2008;26(18):2966-72.

• Asang, C., I. Hauber, and H. Schaal.  Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer. Nucleic Acids Res, 2008, 36:14, 50-1463.

• Becker J., Al-Nawas B., Klein M.O., Schliephake H., Terheyden H., Schwarz F.: Use of a new cross-linked collagen membrane for the treatment of dehiscence-type defects at titanium implants. A prospective randomized controlled double blinded clinical multicenter study. Clinical Oral Implants Research, 2009, 20: 742-749.

• Beu M, Baudrexel S, Hautzel H, Antke C, Mueller HW. Neural traffic as voxel-based measure of cerebral functional connectivity in fMRI. J Neurosci Methods. 2009 Jan 30;176(2):263-9. Epub 2008 Sep 12.

• Eckstein N, Servan K, Hildebrandt B, Pölitz A, von Jonquières G, Wolf-Kümmeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 2009 Apr 1;69(7):2996-3003. Epub 2009 Mar 24.

• Engel C, Rahner N, Schulmann K, Holinski-Feder E, Goecke TO, Schackert HK, Kloor M, Steinke V, Vogelsang H, Möslein G, Görgens H, Dechant S, Von Knebel Doeberitz M, Rüschoff J, Friedrichs N, Büttner R, Loeffler M, Propping P, Schmiegel W; German Hnpcc Consortium.Efficacy of Annual Colonoscopic Surveillance in Individuals With Hereditary Nonpolyposis Colorectal Cancer. Clin Gastroenterol Hepatol. 2009 Oct 14. [Epub ahead of print] PMID: 19835992.

• Eickhoff, S.B., Rottschy, C., Kujovic, M., Palomero-Gallagher, N., Schleicher, A., Zilles, K.: Organizational principles of human visual cortex revealed by receptor mapping. Cerebral Cortex 18: 2637-2645 (2008).

• Furth C, Steffen IG, Amthauer H, Ruf J, Misch D, Schönberger S, Kobe C, Denecke T, Stöver B, Hautzel H, Henze G, Hundsdoerfer P; Early and Late Therapy Response Assessment With [18F]Fluorodeoxyglucose Positron Emission Tomography in Pediatric Hodgkin''s Lymphoma: Analysis of a Prospective Multicenter Trial. Journal of Clinical Oncology, Vol 27, No 26 , 2009: 4385-4391.

• Gerber PA, Homey B.: Images in clinical medicine. Erlotinib-induced hair alterations. N Engl J Med. 2008 Mar 13;358(11):1175.

• Hautzel H, Pisar E, Yazdan-Doust N, Schott M, Beu M, Müller HW. Qualitative and quantitative impact of protective glucocorticoid therapy on the effective 131l half-life in radioiodine therapy for Graves disease. J Nucl Med. 2010 Dec; 51(12):1917-22.

• Hautzel H, Müller HW, Herzog H, Grandt R. Cognition-induced modulation of serotonin in the orbitofrontal cortex: A controlled cross-over PET study of a delayed match-to-sample task using the 5-HT2a receptor antagonist [(18)F]altanserin. Neuroimage. 2011 Oct 1;58(3):905-11. Epub 2011 Jun 17.

• Heinzel A, Kley K, Mueller HW, Hautzel H. A comparison of rh-TSH and thyroid hormone withdrawal in patients with differentiated thyroid cancer: preliminary evidence for an influence of age on the subjective well-being in hypothyroidism. Horm Metab Res. 2012 Jan;44(1):54-9.

• Heinzel A, Minnerop M, Schäfer R, Müller HW, Franz M, Hautzel H. Alexithymia in healthy young men: A voxel-based morphometric study. J Affect Disord. 2012 Feb;136(3):1252-6.

• Heinzel A, Schäfer R, Müller HW, Schieffer A, Ingenhag A, Northoff G, Franz M, Hautzel H. Differential modulation of valence and arousal in high-alexithymic and low-alexithymic individuals. Neuroreport. 2010 Oct 27; 21 (15):998-1002.

• Hendgen-Cotta UB, Merx MW, Shiva S, Schmitz J, Becher S, Klare JP, Steinhoff HJ, Goedecke A, Schrader J, Gladwin MT, Kelm M, Rassaf T.Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury.Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10256-61.Epub 2008 Jul 16. Erratum in: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12636.

• Hillmer AM, Brockschmidt FF, Hanneken S, Eigelshoven S, Steffens M, Flaquer A, Herms S, Becker T, Kortüm AK, Nyholt DR, Zhao ZZ, Montgomery GW, Martin NG, Mühleisen TW, Alblas MA, Moebus S, Jöckel KH, Bröcker-Preuss M, Erbel R, Reinartz R, Betz RC, Cichon S, Propping P, Baur MP, Wienker TF, Kruse R, Nöthen MM. Susceptibility variants for male-pattern baldness on chromosome 20p11. Nat Genet. 2008 Nov;40(11):1279-81.

• Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, for the EUFEST study group.Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet 2008, 371: 1085-97.

• Krieg A, Correa RG, Garrison JB, Le Negrate G, Welsh K, Huang Z, Knoefel WT, Reed JC.: XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A. 2009 Aug 10. [Epub ahead of print].

• Möller HJ, Riedel M, Jäger M, Wickelmaier F, Maier W, Kühn KU, Buchkremer G, Heuser I, Klosterkötter J, Gastpar M, Braus DF, Schlösser R, Schneider F, Ohmann C, Riesbeck M, Gaebel W.: Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia. Int J Neuropsychopharmacol. 2008 Nov;11(7):985-97. Epub 2008 May 9.

• Michiels S., Le Maitre A., Buyse M., Burzykowski T., Maillard E., Bogaerts J., Vermorken J. B., Budach W., Pajak T. F., Ang K. K., Bourhis J.Pignon J. P.: Surrogate endpoints for overall survival in locally advanced head and neck cancer: meta-analyses of individual patient data. Lancet Oncol, 2009. 10: 341-350.

• Nikolaus S, Antke C, Beu M, Kley K, Wirrwar A, Huston JP, Müller HW. Binding of [123I]iodobenzamide to the rat D2 receptor after challenge with various doses of methylphenidate: an in vivo imaging study with dedicated small animal SPECT. Eur J Nucl Med Mol Imaging. 2011 Apr;38(4):694-701. Epub 2010 Nov 26.

• Nikolaus S, Larisch R, Vosberg H, Beu M, Wirrwar A, Antke C, Kley K, Silva MA, Huston JP, Müller HW.Pharmacological challenge and synaptic response - assessing dopaminergic function in the rat striatum with small animal single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Rev Neurosci. 2011;22(6):625-45.

• Ohmann C, Kuchinke W: Future developments of medical informatics from the viewpoint of networked clinical research. Interoperability and integration. Methods Inf Med, 2009;48(1):45-54.

• Onofre Fabiana Botelho de Miranda, Onofre Alexandre Sherlley Casimiro, Pomjanski Natalia, Buckstegge Birgit, Grote Hans Juergen, Böcking Alfred: 9p21 Deletion in the diagnosis of malignant mesothelioma in serous effusions additional to immunocytochemistry, DNA-ICM, and AgNOR analysis. Cancer 2008;114(3):204-15.

• Pape R, Rauch BH, Rosenkranz AC, Kaber G, Schrör K.<small>Transcriptional inhibition of protease-activated receptor-1 expression by prostacyclin in human vascular smooth muscle cells. </small>Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):534-40. Epub 2007 Dec 27.

• Paunel-Görgülü A, Zörnig M, Lögters T, Altrichter J, Rabenhorst U, Cinatl J, Windolf J, Scholz M. Mcl-1-mediated impairment of the intrinsic apoptosis pathway in circulating neutrophils from critically ill patients can be overcome by Fas stimulation. J Immunol. 2009 Nov 15;183(10):6198-206.

• Pollok B, Gross J, Kamp D, Schnitzler A. Evidence for anticipatory motor control within a cerebello-diencephalic-parietal network. Journal of  Cognitive Neuroscience, 20: 828-40, 2008.

• Rauch, A, Thiel, C, Schindler, D, Wick, U, Crow, Y.J, Ekici, A.B, van Essen, A, Goecke, T.O, Al-Gazali, L, Chrzanowska, K.H, Zweier, C, Brunner, H.G, Becker, K, Curry, C.J, Dallapiccola, B, Devriendt, K, Dörfler, A, Kinning, E, Megarbane, A, Meinecke, P, Semple, R.K, Spranger, S, Toutain, A, Trembath, R.C, Voss, E, Wilson, L, Hennekam, R, de Zegher, F, Dörr, H.-G, Reis: Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science. 2008; 319: 816.

• Royer-Pokora B, Busch M, Beier M, Duhme C, de Torres C, Mora J, Brandt A, Royer HD: Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm. Hum Mol Genet. 2010; May;1;19(9):1651-68.

• Sabir H, Mayatepek E, Schaper J, Tibussek D: Baby-walkers: an avoidable source of hazard. Lancet 2008; 6; 372 (9654): 2000.

• Sawitza, I., Kordes, C., Reister, S., & Häussinger, D.: The niche of stellate cells within rat liver. Hepatology. 2009 DOI:

  10.1002/hep.23184.

• Schuetz C, Huck K, Gudowius S, Megahed M, Feyen O, Hubner B, Schneider DT, Manfras B, Pannicke U, Willemze R, Knüchel R, Göbel U, Schulz A, Borkhardt A, Friedrich W, Schwarz K, Niehues T.: An immunodeficiency disease with RAG mutations and granulomas. N Engl J Med. 2008 May 8;358(19):2030-8.

• Stoecklein NH, Hosch SB, Bezler M, Stern F, Hartmann CH, Vay C, Siegmund A, Scheunemann P, Schurr P, Knoefel WT, Verde PE, Reichelt U, Erbersdobler A, Grau R, Ullrich A, Izbicki JR, Klein CA.: Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer Cell. 2008 May;13(5):441-53.

• Südmeyer M, Antke C, Zizek T, Beu M, Nikolaus S, Wojtecki L, Schnitzler A, Müller HW.: Diagnostic accuracy of combined FP-CIT, IBZM, and MIBG scintigraphy in the differential diagnosis of degenerative parkinsonism: a multidimensional statistical approach. J Nucl Med. 2011 May;52(5):733-40. Epub 2011 Apr 15.

• Szendroedi J, Chmelik M, Schmid AI, Nowotny P, Brehm A, Krssak M, Moser E,Roden M.: Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology. 2009 May 26. [Epub ahead of print]

• Thiel A, Beier M, Ingenhag D, Servan K, Hein M, Moeller V, Betz B, Hildebrandt B, Evers C, Germing U, Royer-Pokora B.: Comprehensive array CGH of normal karyotype myelodysplastic syndromes reveals hidden recurrent and individual genomic copy number alterations with prognostic relevance. Leukemia 2011 Jan. 28  [Epub ahead of print]

• Verde, Pablo E.: Meta-analysis of diagnostic test data: A bivariate Bayesian modeling approach. Statistics in Medicine, Volume 29, Issue 30, pages 3088-3102, 30 December 2010. 

• Wege N, Dragano N, Moebus S, Stang A, Erbel R, Jöckel KH, Siegrist J.: When does work stress hurt? Testing the interaction with socioeconomic status in the Heinz Nixdorf Recall Study. Journal of Epidemiology & Community Health; 62:338-341.